Version 5.4
Bos taurus Gene: GRIN2B
Summary
InnateDB Gene IDBG-639363.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRIN2B
Gene Name glutamate
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000219
Encoded Proteins
IDBP-691514
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:96408804-96761516
Strand Forward strand
Band
Transcripts
ENSBTAT00000000263 ENSBTAP00000000263
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 83 interaction(s) predicted by orthology.
Predicted by orthology
Total 83 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004970 ionotropic glutamate receptor activity
GO:0004972 N-methyl-D-aspartate selective glutamate receptor activity
GO:0005215 transporter activity
GO:0005216 ion channel activity
GO:0005234 extracellular-glutamate-gated ion channel activity
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0016594 glycine binding
Biological Process
GO:0001662 behavioral fear response
GO:0001701 in utero embryonic development
GO:0001964 startle response
GO:0001967 suckling behavior
GO:0006810 transport
GO:0006811 ion transport
GO:0006812 cation transport
GO:0006816 calcium ion transport
GO:0007268 synaptic transmission
GO:0007423 sensory organ development
GO:0007612 learning
GO:0007613 memory
GO:0034220 ion transmembrane transport
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035249 synaptic transmission, glutamatergic
GO:0042596 fear response
GO:0045471 response to ethanol
GO:0048167 regulation of synaptic plasticity
GO:0048266 behavioral response to pain
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0060078 regulation of postsynaptic membrane potential
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0017146 N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054 cell junction
GO:0030425 dendrite
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0097481 neuronal postsynaptic density
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
null
View Gene Order
ENSMUSG00000030209
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
mmu05010
Alzheimer's disease pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
mmu04720
Long-term potentiation pathway
mmu05014
Amyotrophic lateral sclerosis (ALS) pathway
mmu05322
Systemic lupus erythematosus pathway
mmu05016
Huntington's disease pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MCL3
UniProt Splice Variant
Entrez Gene 537804
UniGene Bt.61353
RefSeq NM_001192921 XM_005206987 XM_005206988 XM_005206989
HUGO HGNC:4586
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02014253 DAAA02014254 DAAA02014255 DAAA02014256 DAAA02014257 DAAA02014258 DAAA02014259 DAAA02014260 DAAA02014261 DAAA02014262 DAAA02014263
GenPept
RNA Seq Atlas 537804

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca