Version 5.4
Bos taurus Gene: BT.62405
Summary
InnateDB Gene IDBG-639486.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.62405
Gene Name zinc finger protein Aiolos
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000011003
Encoded Proteins
IDBP-691656
zinc finger protein Aiolos
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161405:
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:40779127-40864311
Strand Reverse strand
Band
Transcripts
ENSBTAT00000014617 ENSBTAP00000014617
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0030888 regulation of B cell proliferation
GO:0042981 regulation of apoptotic process
GO:0045577 regulation of B cell differentiation
GO:0045619 regulation of lymphocyte differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000161405
View Gene Order
ENSMUSG00000018168
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
il2_1pathway
IL2-mediated signaling events
Cross-References
SwissProt
TrEMBL G5E5E5
UniProt Splice Variant
Entrez Gene 540676
UniGene Bt.62405
RefSeq NM_001081613
HUGO HGNC:13178
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02049124 DAAA02049125 DAAA02049126 DAAA02049127
GenPept
RNA Seq Atlas 540676

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca