Version 5.4
Bos taurus Gene: BT.64623
Summary
InnateDB Gene IDBG-639507.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.64623
Gene Name protein SET
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020959
Encoded Proteins
IDBP-691675
protein SET
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119335:
The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:99223002-99226827
Strand Forward strand
Band
Transcripts
ENSBTAT00000027913 ENSBTAP00000027913
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 126 interaction(s) predicted by orthology.
Predicted by orthology
Total 126 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006334 nucleosome assembly
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000119335
View Gene Order
ENSMUSG00000054766
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25218
HuR stabilizes mRNA pathway
REACT_172744
Condensation of Prophase Chromosomes pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_765
Mitotic Prophase pathway
REACT_24994
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_71
Gene Expression pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_198687
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_198691
HuR stabilizes mRNA pathway
REACT_188804
Cell Cycle pathway
REACT_241408
M Phase pathway
REACT_196580
Condensation of Prophase Chromosomes pathway
REACT_233572
Gene Expression pathway
REACT_250557
Mitotic Prophase pathway
KEGG
INOH
PID NCI
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
Cross-References
SwissProt
TrEMBL F1MCF1
UniProt Splice Variant
Entrez Gene 538444
UniGene Bt.62904
RefSeq NM_001038564
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02032185
GenPept
RNA Seq Atlas 538444

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca