InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SET

Summary

InnateDB Gene

IDBG-88484.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SET

Gene Name

SET nuclear oncogene

Synonyms

2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII; TAF-I; TAF-IBETA

Species

Homo sapiens

Ensembl Gene

ENSG00000119335

Encoded Proteins

IDBP-88486

SET nuclear oncogene

IDBP-88488

SET nuclear oncogene

IDBP-88490

SET nuclear oncogene

IDBP-88492

SET nuclear oncogene

IDBP-294603

SET nuclear oncogene

IDBP-381835

SET nuclear oncogene

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:128683424-128696400

Strand

Forward strand

Band

q34.11

Transcripts

ENST00000372692	ENSP00000361777
ENST00000322030	ENSP00000318012
ENST00000372688	ENSP00000361773
ENST00000372686	ENSP00000361771
ENST00000409104	ENSP00000387321
ENST00000454747	ENSP00000410806
ENST00000466009
ENST00000477806
ENST00000480217
ENST00000480536
ENST00000485056

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 149 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	149 [view]
Protein-Protein	147 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004864	protein phosphatase inhibitor activity
GO:0005515	protein binding
GO:0008601	protein phosphatase type 2A regulator activity
GO:0042393	histone binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0006334	nucleosome assembly
GO:0006337	nucleosome disassembly
GO:0006913	nucleocytoplasmic transport
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0035067	negative regulation of histone acetylation
GO:0043086	negative regulation of catalytic activity
GO:0043524	negative regulation of neuron apoptotic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0050790	regulation of catalytic activity

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm