InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: EPS15

Summary

InnateDB Gene

IDBG-639596.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPS15

Gene Name

epidermal growth factor receptor substrate 15

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005542

Encoded Proteins

IDBP-691783

epidermal growth factor receptor substrate 15

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000085832:
This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:95389092-95528688

Strand

Forward strand

Band

Transcripts

ENSBTAT00000053382

ENSBTAP00000052345

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 100 interaction(s) predicted by orthology.

Predicted by orthology
Total	100 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0031593	polyubiquitin binding
GO:0042802	identical protein binding

Biological Process

GO:0006895	Golgi to endosome transport
GO:0048268	clathrin coat assembly

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0016020	membrane
GO:0030122	AP-2 adaptor complex
GO:0030132	clathrin coat of coated pit
GO:0030136	clathrin-coated vesicle
GO:0043231	intracellular membrane-bounded organelle
GO:0060170	ciliary membrane