Bos taurus Gene: CDKN2C | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Gene | IDBG-639655.3 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | CDKN2C | ||||||||||||||
Gene Name | cyclin-dependent kinase 4 inhibitor C | ||||||||||||||
Synonyms | |||||||||||||||
Species | Bos taurus | ||||||||||||||
Ensembl Gene | ENSBTAG00000011059 | ||||||||||||||
Encoded Proteins |
cyclin-dependent kinase 4 inhibitor C
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Protein Structure | |||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
Entrez Gene | |||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123080:
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||
Type | Protein coding | ||||||||||||||
Genomic Location | Chromosome 3:95924172-95928574 | ||||||||||||||
Strand | Reverse strand | ||||||||||||||
Band | |||||||||||||||
Transcripts |
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Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||
NETPATH | |||||||||||||||
REACTOME |
Cyclin D associated events in G1 pathway
G1 Phase pathway
Cellular responses to stress pathway
Oncogene Induced Senescence pathway
Mitotic G1-G1/S phases pathway
Cell Cycle pathway
Cellular Senescence pathway
Cell Cycle, Mitotic pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Oxidative Stress Induced Senescence pathway
Oxidative Stress Induced Senescence pathway
Cell Cycle, Mitotic pathway
G1 Phase pathway
Cellular responses to stress pathway
Oncogene Induced Senescence pathway
Cell Cycle pathway
Cyclin D associated events in G1 pathway
Cellular Senescence pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Mitotic G1-G1/S phases pathway
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KEGG |
Cell cycle pathway
Cell cycle pathway
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INOH |
Hedgehog signaling pathway pathway
Hedgehog signaling pathway pathway
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PID NCI |
E2F transcription factor network
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Cross-References | |||||||||||||||
SwissProt | |||||||||||||||
TrEMBL | |||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | |||||||||||||||
UniGene | Bt.55596 | ||||||||||||||
RefSeq | NM_001101054 | ||||||||||||||
HUGO | |||||||||||||||
OMIM | |||||||||||||||
CCDS | |||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | |||||||||||||||
GenPept | |||||||||||||||
RNA Seq Atlas | |||||||||||||||