Version 5.4
Bos taurus Gene: PPP5C
Summary
InnateDB Gene IDBG-639819.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP5C
Gene Name serine/threonine-protein phosphatase 5
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000008014
Encoded Proteins
IDBP-692012
Serine/threonine-protein phosphatase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000011485:
This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:54025021-54045583
Strand Forward strand
Band
Transcripts
ENSBTAT00000010538 ENSBTAP00000010538
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Predicted by orthology
Total 40 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0004721 phosphoprotein phosphatase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0007165 signal transduction
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043278 response to morphine
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000011485
View Gene Order
ENSMUSG00000003099
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
mmu04010
MAPK signaling pathway pathway
INOH
PID NCI
erbb1_downstream_pathway
ErbB1 downstream signaling
reg_gr_pathway
Glucocorticoid receptor regulatory network
Cross-References
SwissProt
TrEMBL F1N719 Q0V8L5 Q0V8M3
UniProt Splice Variant
Entrez Gene 510245
UniGene Bt.55643
RefSeq NM_001192249
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BT026195 BT026203 DAAA02047392
GenPept ABG67034 ABG67042
RNA Seq Atlas 510245

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca