InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ppp5c

Summary

InnateDB Gene

IDBG-147416.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppp5c

Gene Name

protein phosphatase 5, catalytic subunit

Synonyms

AU020526; PP5

Species

Mus musculus

Ensembl Gene

ENSMUSG00000003099

Encoded Proteins

IDBP-147418

protein phosphatase 5, catalytic subunit

IDBP-536733

protein phosphatase 5, catalytic subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000011485:
This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:17004640-17027924

Strand

Reverse strand

Band

Transcripts

ENSMUST00000003183	ENSMUSP00000003183
ENSMUST00000142597	ENSMUSP00000122783
ENSMUST00000142831
ENSMUST00000124573
ENSMUST00000138353
ENSMUST00000154880
ENSMUST00000156366
ENSMUST00000146920
ENSMUST00000127311
ENSMUST00000153242
ENSMUST00000145997

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	39 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004721	phosphoprotein phosphatase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0007165	signal transduction
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043278	response to morphine
GO:0051291	protein heterooligomerization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000011485

View Gene Order

ENSBTAG00000008014

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04010

MAPK signaling pathway pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04010

MAPK signaling pathway pathway

INOH

PID NCI

erbb1_downstream_pathway

ErbB1 downstream signaling

reg_gr_pathway

Glucocorticoid receptor regulatory network

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.3294 Mm.475000

RefSeq

NM_011155 XM_006539664

OMIM

CCDS

CCDS20859

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas