InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SPHK2

Summary

InnateDB Gene

IDBG-640229.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPHK2

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009872

Encoded Proteins

IDBP-692475

sphingosine kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000063176:
This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:55714370-55721629

Strand

Forward strand

Band

Transcripts

ENSBTAT00000013019

ENSBTAP00000013019

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005515	protein binding
GO:0017050	D-erythro-sphingosine kinase activity

Biological Process

GO:0001568	blood vessel development
GO:0006670	sphingosine metabolic process
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007420	brain development
GO:0008152	metabolic process
GO:0008284	positive regulation of cell proliferation
GO:0016310	phosphorylation