InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PDE11A

Summary

InnateDB Gene

IDBG-640255.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE11A

Gene Name

dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016396

Encoded Proteins

IDBP-692515

phosphodiesterase 11A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128655:
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:18823638-19247733

Strand

Forward strand

Band

Transcripts

ENSBTAT00000021805

ENSBTAP00000021805

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity
GO:0016787	hydrolase activity
GO:0030553	cGMP binding
GO:0046872	metal ion binding