Version 5.4
Bos taurus Gene: GFI1B
Summary
InnateDB Gene IDBG-640274.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GFI1B
Gene Name zinc finger protein Gfi-1b
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012772
Encoded Proteins
IDBP-692512
growth factor independent 1B transcription repressor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165702:
This gene encodes a zinc-finger containing transcriptional regulator that is primarily expressed in cells of hematopoietic lineage. The encoded protein complexes with numerous other transcriptional regulatory proteins including GATA-1, runt-related transcription factor 1 and histone deacetylases to control expression of genes involved in the development and maturation of erythrocytes and megakaryocytes. Mutations in this gene are the cause of the autosomal dominant platelet disorder, platelet-type bleeding disorder-17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:103039731-103051510
Strand Forward strand
Band
Transcripts
ENSBTAT00000016974 ENSBTAP00000016974
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 77 interaction(s) predicted by orthology.
Predicted by orthology
Total 77 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001085 RNA polymerase II transcription factor binding
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0030854 positive regulation of granulocyte differentiation
GO:0045646 regulation of erythrocyte differentiation
GO:0051572 negative regulation of histone H3-K4 methylation
GO:0051574 positive regulation of histone H3-K9 methylation
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0016363 nuclear matrix
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000165702
View Gene Order
ENSMUSG00000026815
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.43556
RefSeq NM_001192920 XM_005213306 XM_005213307 XM_005213308
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca