Version 5.4
Mus musculus Gene: Gfi1b
Summary
InnateDB Gene IDBG-152546.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gfi1b
Gene Name growth factor independent 1B
Synonyms Gfi-1B
Species Mus musculus
Ensembl Gene ENSMUSG00000026815
Encoded Proteins
IDBP-152548
growth factor independent 1B
IDBP-621819
growth factor independent 1B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165702:
This gene encodes a zinc-finger containing transcriptional regulator that is primarily expressed in cells of hematopoietic lineage. The encoded protein complexes with numerous other transcriptional regulatory proteins including GATA-1, runt-related transcription factor 1 and histone deacetylases to control expression of genes involved in the development and maturation of erythrocytes and megakaryocytes. Mutations in this gene are the cause of the autosomal dominant platelet disorder, platelet-type bleeding disorder-17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:28609450-28621982
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000028156 ENSMUSP00000028156
ENSMUST00000155686
ENSMUST00000145690
ENSMUST00000164290 ENSMUSP00000128052
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 75 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 75 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001085 RNA polymerase II transcription factor binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0030854 positive regulation of granulocyte differentiation
GO:0045646 regulation of erythrocyte differentiation
GO:0051572 negative regulation of histone H3-K4 methylation
GO:0051574 positive regulation of histone H3-K9 methylation
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0016363 nuclear matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000165702
View Gene Order
ENSBTAG00000012772
Not yet available
Cross-References
SwissProt O70237
TrEMBL B7ZNH2
UniProt Splice Variant
Entrez Gene 14582
UniGene Mm.373385
RefSeq NM_001160406 NM_008114
OMIM
CCDS CCDS15843 CCDS50549
HPRD
IMGT
MGI ID MGI:1276578
MGI Symbol Gfi1b
EMBL AF017275 AK157262 AL731851 BC052654 BC132365 BC132367 BC145238
GenPept AAC40088 AAH52654 AAI32366 AAI32368 AAI45239 BAE34016 CAM22291
RNA Seq Atlas 14582

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca