Version 5.4
Bos taurus Gene: DPH2
Summary
InnateDB Gene IDBG-640346.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPH2
Gene Name Diphthamide biosynthesis protein 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018888
Encoded Proteins
IDBP-692600
diphthamide biosynthesis protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132768:
This gene is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:102676689-102680240
Strand Reverse strand
Band
Transcripts
ENSBTAT00000025143 ENSBTAP00000025143
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000132768
View Gene Order
ENSMUSG00000028540
View Gene Order
Cross-References
SwissProt Q08DM2
TrEMBL
UniProt Splice Variant
Entrez Gene 768224
UniGene Bt.15775
RefSeq NM_001078099
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123671 BT030476
GenPept AAI23672 ABQ12916
RNA Seq Atlas 768224

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca