InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SIRPA

Summary

InnateDB Gene

IDBG-640348.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SIRPA

Gene Name

tyrosine-protein phosphatase non-receptor type substrate 1 precursor

Synonyms

MYD-1; PTPNS1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007213

Encoded Proteins

IDBP-692604

tyrosine-protein phosphatase non-receptor type substrate 1

IDBP-692609

tyrosine-protein phosphatase non-receptor type substrate 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18233962

[Homo sapiens] SIRPA negatively regulates TLR4 or TLR3 dependent cytokine production through inhibition of NF-kappaB dependent signalling.

PMID 17954568

[Homo sapiens] SIRPA down-regulation is lipopolysaccharide (LPS) inducible and contributes to innate immune activation in macrophages.

PMID 25538234

[Mus musculus] Ptpn11 phosphatase function positively regulates Clec7a- and Itgam-stimulated reactive oxygen species production in macrophages by dephosphorylating and thus mitigating the inhibitory function of Sirpa and by promoting Mapk1/Mapk3 activation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198053:
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:53667570-53710792

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000038306	ENSBTAP00000038121
ENSBTAT00000009488	ENSBTAP00000009488

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.