Version 5.4
Bos taurus Gene: EZH1
Summary
InnateDB Gene IDBG-640409.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EZH1
Gene Name Histone-lysine N-methyltransferase EZH1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021918
Encoded Proteins
IDBP-692685
histone-lysine N-methyltransferase EZH1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108799:
EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).[supplied by OMIM, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:43395930-43428213
Strand Reverse strand
Band
Transcripts
ENSBTAT00000029222 ENSBTAP00000029222
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0016740 transferase activity
GO:0018024 histone-lysine N-methyltransferase activity
GO:0046976 histone methyltransferase activity (H3-K27 specific)
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016568 chromatin modification
GO:0032259 methylation
GO:0070734 histone H3-K27 methylation
Cellular Component
GO:0005634 nucleus
GO:0035098 ESC/E(Z) complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000108799
View Gene Order
ENSMUSG00000006920
View Gene Order
Cross-References
SwissProt A7E2Z2
TrEMBL
UniProt Splice Variant
Entrez Gene 533087
UniGene Bt.21818
RefSeq NM_001102151
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC151626
GenPept AAI51627
RNA Seq Atlas 533087

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca