Version 5.4
Bos taurus Gene: CHN1
Summary
InnateDB Gene IDBG-640413.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHN1
Gene Name N-chimaerin isoform 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000008028
Encoded Proteins
IDBP-692677
N-chimaerin isoform 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128656:
This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane\'s retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:21880323-22081286
Strand Forward strand
Band
Transcripts
ENSBTAT00000010556 ENSBTAP00000010556
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0046875 ephrin receptor binding
Biological Process
GO:0007165 signal transduction
GO:0008045 motor neuron axon guidance
GO:0032314 regulation of Rac GTPase activity
GO:0035556 intracellular signal transduction
GO:0048013 ephrin receptor signaling pathway
GO:0050770 regulation of axonogenesis
Cellular Component
GO:0005622 intracellular
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000128656
View Gene Order
ENSMUSG00000056486
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
REACT_206918
Signaling by Rho GTPases pathway
REACT_210090
Rho GTPase cycle pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
rac1_reg_pathway
Regulation of RAC1 activity
Cross-References
SwissProt
TrEMBL A7Z037
UniProt Splice Variant
Entrez Gene 508266
UniGene Bt.53955 Bt.70789
RefSeq NM_001113247 XM_005202319
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC153235 DAAA02004194 DAAA02004195 DAAA02004196
GenPept AAI53236
RNA Seq Atlas 508266

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca