Version 5.4
Bos taurus Gene: GUCA2B
Summary
InnateDB Gene IDBG-640640.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GUCA2B
Gene Name guanylate cyclase activator 2B precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007194
Encoded Proteins
IDBP-692920
guanylate cyclase activator 2B (uroguanylin)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000044012:
This gene encodes a member of the guanylin family, and is expressed in the stomach and intestine. This protein functions as an endogenous ligand for the guanylate cyclase-C receptor and stimulates an increase in cyclic GMP, a key component of several intracellular signal transduction pathways. It maybe involved in salt and water secretion into the intestinal lumen as well as the renal tubules, and thus regulate electrolyte homeostasis in these tissues. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:104609131-104612391
Strand Reverse strand
Band
Transcripts
ENSBTAT00000009465 ENSBTAP00000009465
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008047 enzyme activator activity
GO:0030250 guanylate cyclase activator activity
Biological Process
GO:0006182 cGMP biosynthetic process
GO:0007588 excretion
GO:0007589 body fluid secretion
GO:0043085 positive regulation of catalytic activity
GO:0045776 negative regulation of blood pressure
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000044012
View Gene Order
ENSMUSG00000032978
View Gene Order
Cross-References
SwissProt
TrEMBL E1BIM1
UniProt Splice Variant
Entrez Gene 515664
UniGene Bt.61300
RefSeq NM_001205816
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02009085
GenPept
RNA Seq Atlas 515664

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca