InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ARFGAP3

Summary

InnateDB Gene

IDBG-640695.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARFGAP3

Gene Name

ADP-ribosylation factor GTPase-activating protein 1

Synonyms

ARFGAP3

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004916

Encoded Proteins

IDBP-692986

ADP-ribosylation factor GTPase-activating protein 1

IDBP-692989

ADP-ribosylation factor GTPase-activating protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101199:
The protein encoded by this gene is a GTPase-activating protein (GAP) which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1 (ARF1). The encoded protein promotes hydrolysis of ARF1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:54759402-54769733

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000056498	ENSBTAP00000052344
ENSBTAT00000006468	ENSBTAP00000006468

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0008060	ARF GTPase activator activity
GO:0008270	zinc ion binding
GO:0046872	metal ion binding