Version 5.4
Homo sapiens Gene: ARFGAP1
Summary
InnateDB Gene IDBG-85926.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARFGAP1
Gene Name ADP-ribosylation factor GTPase activating protein 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101199
Encoded Proteins
IDBP-85928
ADP-ribosylation factor GTPase activating protein 1
IDBP-85930
ADP-ribosylation factor GTPase activating protein 1
IDBP-85932
ADP-ribosylation factor GTPase activating protein 1
IDBP-482540
ADP-ribosylation factor GTPase activating protein 1
IDBP-477373
ADP-ribosylation factor GTPase activating protein 1
IDBP-482443
ADP-ribosylation factor GTPase activating protein 1
IDBP-475569
ADP-ribosylation factor GTPase activating protein 1
IDBP-484490
ADP-ribosylation factor GTPase activating protein 1
IDBP-483950
ADP-ribosylation factor GTPase activating protein 1
IDBP-584790
ADP-ribosylation factor GTPase activating protein 1
IDBP-603932
ADP-ribosylation factor GTPase activating protein 1
IDBP-592327
ADP-ribosylation factor GTPase activating protein 1
IDBP-603927
ADP-ribosylation factor GTPase activating protein 1
IDBP-592221
ADP-ribosylation factor GTPase activating protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a GTPase-activating protein (GAP) which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1 (ARF1). The encoded protein promotes hydrolysis of ARF1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:63272785-63289793
Strand Forward strand
Band q13.33
Transcripts
ENST00000370283 ENSP00000359306
ENST00000353546 ENSP00000314615
ENST00000370275 ENSP00000359298
ENST00000395285
ENST00000523114 ENSP00000428355
ENST00000522959
ENST00000523460 ENSP00000429770
ENST00000519604 ENSP00000430500
ENST00000520485 ENSP00000427717
ENST00000524192
ENST00000519531
ENST00000518601 ENSP00000429674
ENST00000522403 ENSP00000430929
ENST00000519273 ENSP00000443716
ENST00000520022
ENST00000518794
ENST00000518691
ENST00000468975
ENST00000518618
ENST00000547204 ENSP00000449800
ENST00000549047 ENSP00000447037
ENST00000550188 ENSP00000449515
ENST00000549076 ENSP00000449849
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 33 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
Biological Process
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0015031 protein transport
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0032312 regulation of ARF GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0044267 cellular protein metabolic process
GO:0048205 COPI coating of Golgi vesicle
GO:0061024 membrane organization
Cellular Component
GO:0000139 Golgi membrane
GO:0005829 cytosol
GO:0030660 Golgi-associated vesicle membrane
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027575
View Gene Order
ENSBTAG00000004916
Not yet available
Pathways
NETPATH
REACTOME
REACT_18273
XBP1(S) activates chaperone genes pathway
REACT_18368
IRE1alpha activates chaperones pathway
REACT_11096
COPI Mediated Transport pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_17015
Metabolism of proteins pathway
REACT_11208
Golgi to ER Retrograde Transport pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
arf_3pathway
Arf1 pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.708959 Hs.740420
RefSeq NM_001281482 NM_001281483 NM_001281484 NM_018209 NM_175609 XM_006723823 XM_006723824
HUGO
OMIM
CCDS CCDS13515 CCDS13516 CCDS63326 CCDS63327 CCDS63328
HPRD 06443
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca