InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TAF6

Summary

InnateDB Gene

IDBG-640698.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF6

Gene Name

transcription initiation factor TFIID subunit 6

Synonyms

p80; TAFII-70; TAFII-80

Species

Bos taurus

Ensembl Gene

ENSBTAG00000030966

Encoded Proteins

IDBP-692993

transcription initiation factor TFIID subunit 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106290:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:36874497-36881803

Strand

Forward strand

Band

Transcripts

ENSBTAT00000054282

ENSBTAP00000048341

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006352	DNA-templated transcription, initiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0008285	negative regulation of cell proliferation
GO:0045786	negative regulation of cell cycle
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity