InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HDAC5

Summary

InnateDB Gene

IDBG-640847.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HDAC5

Gene Name

histone deacetylase 5

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016254

Encoded Proteins

IDBP-693161

histone deacetylase 5

IDBP-693163

histone deacetylase 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108840:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:44538303-44575554

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000061581	ENSBTAP00000053450
ENSBTAT00000038317	ENSBTAP00000038132

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 304 interaction(s) predicted by orthology.

Predicted by orthology
Total	304 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0004407	histone deacetylase activity
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0016787	hydrolase activity
GO:0044212	transcription regulatory region DNA binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002076	osteoblast development
GO:0007507	heart development
GO:0008152	metabolic process
GO:0010832	negative regulation of myotube differentiation
GO:0016568	chromatin modification
GO:0016575	histone deacetylation
GO:0033555	multicellular organismal response to stress
GO:0042220	response to cocaine
GO:0043393	regulation of protein binding
GO:0045668	negative regulation of osteoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048742	regulation of skeletal muscle fiber development
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051153	regulation of striated muscle cell differentiation
GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis