InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: EHMT1

Summary

InnateDB Gene

IDBG-640904.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EHMT1

Gene Name

histone-lysine N-methyltransferase EHMT1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012148

Encoded Proteins

IDBP-693220

histone-lysine N-methyltransferase, H3 lysine-9 specific 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000181090:
The protein encoded by this gene is a histone methyltransferase that is part of the E2F6 complex, which represses transcription. The encoded protein methylates the Lys-9 position of histone H3, which tags it for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:105429172-105493391

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000016118

ENSBTAP00000016118

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008270	zinc ion binding
GO:0016279	protein-lysine N-methyltransferase activity
GO:0016740	transferase activity
GO:0018024	histone-lysine N-methyltransferase activity
GO:0046974	histone methyltransferase activity (H3-K9 specific)
GO:0046976	histone methyltransferase activity (H3-K27 specific)
GO:0070742	C2H2 zinc finger domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006306	DNA methylation
GO:0009790	embryo development
GO:0016568	chromatin modification
GO:0016571	histone methylation
GO:0018026	peptidyl-lysine monomethylation
GO:0018027	peptidyl-lysine dimethylation
GO:0032259	methylation
GO:0034968	histone lysine methylation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051567	histone H3-K9 methylation
GO:0070734	histone H3-K27 methylation