InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MACF1

Summary

InnateDB Gene

IDBG-640907.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MACF1

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021024

Encoded Proteins

IDBP-693319

microtubule-actin crosslinking factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127603:
The protein encoded by this gene belongs to the plakin family of cytoskeletal linker proteins. This protein family forms bridges between different cytoskeletal elements through specialized modular domains. The encoded protein is one of the largest size proteins identified in human cytoskeletal proteins. It has functional actin and microtubule binding domains, and it appears to stabilize actin at sites where microtubules and microfilaments meet. It may function in microtubule dynamics to facilitate actin-microtubule interactions at the cell periphery and to couple the microtubule network to cellular junctions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
This gene encodes a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. The encoded protein is a member of a family of proteins that form bridges between different cytoskeletal elements. This protein facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:107180352-107389223

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000033270

ENSBTAP00000033188

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003779	actin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0016887	ATPase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0007050	cell cycle arrest
GO:0016055	Wnt signaling pathway
GO:0032886	regulation of microtubule-based process
GO:0043001	Golgi to plasma membrane protein transport

Cellular Component

GO:0005794	Golgi apparatus
GO:0005856	cytoskeleton
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0032587	ruffle membrane

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000127603

View Gene Order

ENSMUSG00000028649

View Gene Order

Cross-References

SwissProt

TrEMBL

F1N6H4

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

HGNC:13664

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02009143 DAAA02009144 DAAA02009145 DAAA02009146 DAAA02009147 DAAA02009148 DAAA02009149

GenPept

RNA Seq Atlas