Version 5.4
Bos taurus Gene: VRK3
Summary
InnateDB Gene IDBG-640918.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VRK3
Gene Name Inactive serine/threonine-protein kinase VRK3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000005367
Encoded Proteins
IDBP-693225
Inactive serine/threonine-protein kinase VRK3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105053:
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation activity. The protein, however, likely retains its substrate binding capability. This gene is widely expressed in human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:56748766-56784317
Strand Reverse strand
Band
Transcripts
ENSBTAT00000007054 ENSBTAP00000007054
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019903 protein phosphatase binding
Biological Process
GO:0006468 protein phosphorylation
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0070373 negative regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000105053
View Gene Order
ENSMUSG00000002205
View Gene Order
Cross-References
SwissProt Q2YDN8
TrEMBL
UniProt Splice Variant
Entrez Gene 520302
UniGene Bt.17255
RefSeq NM_001046251 XM_005219279 XM_005219280 XM_005219281
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC110135
GenPept AAI10136
RNA Seq Atlas 520302

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca