Bos taurus Gene: EFTUD2
Summary
InnateDB Gene IDBG-641015.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EFTUD2
Gene Name 116 kDa U5 small nuclear ribonucleoprotein component
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013526
Encoded Proteins
116 kDa U5 small nuclear ribonucleoprotein component
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] EFTUD2 is a novel innate immune regulator that restricts hepatitis C virus infection through an RIG-I/MDA5-mediated, JAK-STAT-independent pathway.
[Homo sapiens] EFTUD2 is a novel innate immune antiviral regulator that restricts hepatitis C virus infection through a DDX58/IFIH1-mediated, JAK-STAT-independent pathway.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108883:
This gene encodes a GTPase which is a component of the spliceosome complex which processes precursor mRNAs to produce mature mRNAs. Mutations in this gene are associated with mandibulofacial dysostosis with microcephaly. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:45197098-45233617
Strand Reverse strand
Band
Transcripts
ENSBTAT00000017986 ENSBTAP00000017986
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 85 interaction(s) predicted by orthology.
Predicted by orthology
Total 85 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007264 small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0015030 Cajal body
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
mRNA Splicing - Minor Pathway pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
mRNA Splicing pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
mRNA Splicing pathway
mRNA Splicing - Minor Pathway pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
KEGG
Spliceosome pathway
Spliceosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.12887
RefSeq NM_001083396 XM_005220842
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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