Version 5.4
Bos taurus Gene: BT.17865
Summary
InnateDB Gene IDBG-641032.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.17865
Gene Name nostrin
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000010362
Encoded Proteins
IDBP-693353
nostrin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163072:
Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:27317638-27380506
Strand Reverse strand
Band
Transcripts
ENSBTAT00000013682 ENSBTAP00000013682
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0045892 negative regulation of transcription, DNA-templated
GO:0050999 regulation of nitric-oxide synthase activity
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000163072
View Gene Order
ENSMUSG00000034738
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12541
NOSTRIN mediated eNOS trafficking pathway
REACT_12389
eNOS activation and regulation pathway
REACT_12508
Metabolism of nitric oxide pathway
REACT_111217
Metabolism pathway
REACT_204801
eNOS activation and regulation pathway
REACT_215995
NOSTRIN mediated eNOS trafficking pathway
REACT_188937
Metabolism pathway
REACT_208364
Metabolism of nitric oxide pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MKH2
UniProt Splice Variant
Entrez Gene 521834
UniGene Bt.17865
RefSeq NM_001046257 XM_005202334
HUGO HGNC:20203
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02004289
GenPept
RNA Seq Atlas 521834

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca