Bos taurus Gene: CYP2E1 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-641093.3 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | CYP2E1 | ||||||||||||||||||
Gene Name | cytochrome P450 2E1 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||
Ensembl Gene | ENSBTAG00000018365 | ||||||||||||||||||
Encoded Proteins |
cytochrome P450 2E1
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130649:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 26:50550575-50561259 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | |||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
CYP2E1 reactions pathway
Xenobiotics pathway
Cytochrome P450 - arranged by substrate type pathway
Metabolism pathway
Biological oxidations pathway
Phase 1 - Functionalization of compounds pathway
Cytochrome P450 - arranged by substrate type pathway
Phase 1 - Functionalization of compounds pathway
Metabolism pathway
CYP2E1 reactions pathway
Biological oxidations pathway
Xenobiotics pathway
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KEGG |
Arachidonic acid metabolism pathway
Linoleic acid metabolism pathway
Steroid hormone biosynthesis pathway
Metabolism of xenobiotics by cytochrome P450 pathway
Drug metabolism pathway
Arachidonic acid metabolism pathway
Linoleic acid metabolism pathway
Metabolism of xenobiotics by cytochrome P450 pathway
Steroid hormone biosynthesis pathway
Drug metabolism pathway
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INOH |
Tryptophan degradation pathway
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PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | Q2TBV4 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 282213 | ||||||||||||||||||
UniGene | Bt.5532 | ||||||||||||||||||
RefSeq | NM_174530 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | |||||||||||||||||||
HPRD | |||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | BC109596 DAAA02059642 | ||||||||||||||||||
GenPept | AAI09597 | ||||||||||||||||||
RNA Seq Atlas | 282213 | ||||||||||||||||||