InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ABCA2

Summary

InnateDB Gene

IDBG-641346.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCA2

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000047254

Encoded Proteins

IDBP-693751

ATP-binding cassette, sub-family A (ABC1), member 2

IDBP-693754

ATP-binding cassette, sub-family A (ABC1), member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107331:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:106209227-106222883

Strand

Forward strand

Band

Transcripts

ENSBTAT00000065373	ENSBTAP00000053939
ENSBTAT00000063417	ENSBTAP00000055211

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0008152	metabolic process
GO:0032383	regulation of intracellular cholesterol transport
GO:0042632	cholesterol homeostasis
GO:0048545	response to steroid hormone