Version 5.4
Bos taurus Gene: INTB3
Summary
InnateDB Gene IDBG-641398.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INTB3
Gene Name integrin beta-3 precursor
Synonyms INTB3
Species Bos taurus
Ensembl Gene ENSBTAG00000009987
Encoded Proteins
IDBP-693759
Integrin beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 23150579
[Homo sapiens] ITGAV::ITGB3 is a sensor and activator of innate immunity to herpes simplex virus-1.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000259207:
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:46968837-47027388
Strand Forward strand
Band
Transcripts
ENSBTAT00000013173 ENSBTAP00000013173
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
Predicted by orthology
Total 47 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0007044 cell-substrate junction assembly
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007275 multicellular organismal development
GO:0030334 regulation of cell migration
GO:0030335 positive regulation of cell migration
GO:0033690 positive regulation of osteoblast proliferation
GO:0060055 angiogenesis involved in wound healing
GO:0070527 platelet aggregation
Cellular Component
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0071133 alpha9-beta1 integrin-ADAM8 complex
Orthologs
Species
Mus musculus
Homo sapiens
Gene ID
Gene Order
ENSMUSG00000020689
View Gene Order
ENSG00000259207
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
NetPath_24
TSLP pathway
REACTOME
REACT_230203
Platelet degranulation pathway
REACT_196644
Syndecan interactions pathway
REACT_224553
Hemostasis pathway
REACT_227951
Signaling by VEGF pathway
REACT_198996
Elastic fibre formation pathway
REACT_198998
Molecules associated with elastic fibres pathway
REACT_206066
Extracellular matrix organization pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_261444
Axon guidance pathway
REACT_216309
Integrin cell surface interactions pathway
REACT_238268
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
REACT_215461
Signal transduction by L1 pathway
REACT_219680
L1CAM interactions pathway
REACT_188576
Developmental Biology pathway
REACT_196606
ECM proteoglycans pathway
REACT_196607
Non-integrin membrane-ECM interactions pathway
REACT_240371
p130Cas linkage to MAPK signaling for integrins pathway
REACT_206166
Response to elevated platelet cytosolic Ca2+ pathway
REACT_188257
Signal Transduction pathway
REACT_246176
Integrin alphaIIb beta3 signaling pathway
REACT_249309
Platelet Aggregation (Plug Formation) pathway
REACT_12519
PECAM1 interactions pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_15443
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
REACT_15381
p130Cas linkage to MAPK signaling for integrins pathway
REACT_15523
Integrin alphaIIb beta3 signaling pathway
REACT_278
Platelet Aggregation (Plug Formation) pathway
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_13552
Integrin cell surface interactions pathway
REACT_150331
Molecules associated with elastic fibres pathway
REACT_150366
Elastic fibre formation pathway
REACT_22272
Signal transduction by L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_118779
Extracellular matrix organization pathway
REACT_12529
Signaling by VEGF pathway
REACT_163942
Syndecan interactions pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_163906
ECM proteoglycans pathway
REACT_163874
Non-integrin membrane-ECM interactions pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_604
Hemostasis pathway
KEGG
mmu04512
ECM-receptor interaction pathway
mmu04640
Hematopoietic cell lineage pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04510
Focal adhesion pathway
mmu05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu05414
Dilated cardiomyopathy pathway
mmu04380
Osteoclast differentiation pathway
mmu04145
Phagosome pathway
hsa04810
Regulation of actin cytoskeleton pathway
hsa04640
Hematopoietic cell lineage pathway
hsa04512
ECM-receptor interaction pathway
hsa04510
Focal adhesion pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa05414
Dilated cardiomyopathy pathway
hsa04380
Osteoclast differentiation pathway
hsa04145
Phagosome pathway
INOH
INOH website
Integrin signaling pathway pathway
INOH website
Integrin signaling pathway pathway
PID NCI
avb3_integrin_pathway
Integrins in angiogenesis
integrin_cs_pathway
Integrin family cell surface interactions
ptp1bpathway
Signaling events mediated by PTP1B
upa_upar_pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
nectin_pathway
Nectin adhesion pathway
ephrinbrevpathway
Ephrin B reverse signaling
il4_2pathway
IL4-mediated signaling events
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
integrin3_pathway
Beta3 integrin cell surface interactions
pdgfrbpathway
PDGFR-beta signaling pathway
arf6_pathway
Arf6 signaling events
avb3_opn_pathway
Osteopontin-mediated events
Cross-References
SwissProt
TrEMBL F1MTN1 Q8MKD3 Q95JC4 Q9TR42
UniProt Splice Variant
Entrez Gene 282642
UniGene Bt.13039
RefSeq NM_001206490
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF506752 AJ297965 DAAA02049290
GenPept AAM33401 CAC42491
RNA Seq Atlas 282642

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca