Bos taurus Gene: CLSPN | |||||||||||
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Summary | |||||||||||
InnateDB Gene | IDBG-641486.3 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | CLSPN | ||||||||||
Gene Name | claspin | ||||||||||
Synonyms | |||||||||||
Species | Bos taurus | ||||||||||
Ensembl Gene | ENSBTAG00000002826 | ||||||||||
Encoded Proteins |
claspin
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Protein Structure | |||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
Entrez Gene | |||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092853:
The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] |
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Gene Information | |||||||||||
Type | Protein coding | ||||||||||
Genomic Location | Chromosome 3:110604436-110630769 | ||||||||||
Strand | Forward strand | ||||||||||
Band | |||||||||||
Transcripts |
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Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||
NETPATH | |||||||||||
REACTOME |
Activation of ATR in response to replication stress pathway
Apoptotic cleavage of cellular proteins pathway
Apoptotic execution phase pathway
G2/M Checkpoints pathway
Apoptosis pathway
Cell Cycle pathway
Cell Cycle Checkpoints pathway
Apoptosis pathway
Apoptotic cleavage of cellular proteins pathway
Cell Cycle pathway
Cell Cycle Checkpoints pathway
G2/M Checkpoints pathway
Activation of ATR in response to replication stress pathway
Apoptotic execution phase pathway
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KEGG | |||||||||||
INOH | |||||||||||
PID NCI |
ATR signaling pathway
PLK1 signaling events
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Cross-References | |||||||||||
SwissProt | |||||||||||
TrEMBL | E1BIR1 | ||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 508363 | ||||||||||
UniGene | Bt.61256 | ||||||||||
RefSeq | NM_001192177 | ||||||||||
HUGO | HGNC:19715 | ||||||||||
OMIM | |||||||||||
CCDS | |||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
EMBL | DAAA02009205 | ||||||||||
GenPept | |||||||||||
RNA Seq Atlas | 508363 | ||||||||||