Version 5.4
Bos taurus Gene: GCAT
Summary
InnateDB Gene IDBG-641495.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GCAT
Gene Name 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000008434
Encoded Proteins
IDBP-693875
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100116:
The degradation of L-threonine to glycine consists of a two-step biochemical pathway involving the enzymes L-threonine dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. L-Threonine is first converted into 2-amino-3-ketobutyrate by L-threonine dehydrogenase. This gene encodes the second enzyme in this pathway, which then catalyzes the reaction between 2-amino-3-ketobutyrate and coenzyme A to form glycine and acetyl-CoA. The encoded enzyme is considered a class II pyridoxal-phosphate-dependent aminotransferase. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 14. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:110125415-110132060
Strand Forward strand
Band
Transcripts
ENSBTAT00000011095 ENSBTAP00000011095
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0008890 glycine C-acetyltransferase activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0008152 metabolic process
GO:0009058 biosynthetic process
GO:0019518 L-threonine catabolic process to glycine
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000100116
View Gene Order
ENSMUSG00000006378
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00260
Glycine, serine and threonine metabolism pathway
mmu00260
Glycine, serine and threonine metabolism pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
INOH website
Glycine Serine metabolism pathway
PID NCI
Cross-References
SwissProt Q0P5L8
TrEMBL
UniProt Splice Variant
Entrez Gene 319141
UniGene Bt.14207
RefSeq NM_001075134
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF195767 BC119870
GenPept AAF44353 AAI19871
RNA Seq Atlas 319141

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca