InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: COPE

Summary

InnateDB Gene

IDBG-641572.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COPE

Gene Name

Coatomer subunit epsilon

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000810

Encoded Proteins

IDBP-693951

Coatomer subunit epsilon

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105669:
The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta\', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:4224033-4242168

Strand

Forward strand

Band

Transcripts

ENSBTAT00000001071

ENSBTAP00000001071

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
GO:0006891	intra-Golgi vesicle-mediated transport
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport

Cellular Component

GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0030126	COPI vesicle coat
GO:0030137	COPI-coated vesicle
GO:0030663	COPI-coated vesicle membrane
GO:0031410	cytoplasmic vesicle