InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.3034

Summary

InnateDB Gene

IDBG-641613.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.3034

Gene Name

cartilage oligomeric matrix protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004630

Encoded Proteins

IDBP-693997

cartilage oligomeric matrix protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105664:
The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:4354380-4361950

Strand

Forward strand

Band

Transcripts

ENSBTAT00000006074

ENSBTAP00000006074

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005201	extracellular matrix structural constituent
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0008201	heparin binding
GO:0043395	heparan sulfate proteoglycan binding

Biological Process

GO:0003417	growth plate cartilage development
GO:0007155	cell adhesion
GO:0030198	extracellular matrix organization
GO:0043066	negative regulation of apoptotic process
GO:0060173	limb development

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome