InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NR4A2

Summary

InnateDB Gene

IDBG-641646.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NR4A2

Gene Name

Nuclear receptor subfamily 4 group A member 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003650

Encoded Proteins

IDBP-694026

Nuclear receptor subfamily 4 group A member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153234:
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:39999717-40017015

Strand

Forward strand

Band

Transcripts

ENSBTAT00000004758

ENSBTAP00000004758

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001666	response to hypoxia
GO:0001764	neuron migration
GO:0001975	response to amphetamine
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007399	nervous system development
GO:0008344	adult locomotory behavior
GO:0009791	post-embryonic development
GO:0010467	gene expression
GO:0010468	regulation of gene expression
GO:0016265	death
GO:0021952	central nervous system projection neuron axonogenesis
GO:0021953	central nervous system neuron differentiation
GO:0021986	habenula development
GO:0030182	neuron differentiation
GO:0030522	intracellular receptor signaling pathway
GO:0031668	cellular response to extracellular stimulus
GO:0034599	cellular response to oxidative stress
GO:0042053	regulation of dopamine metabolic process
GO:0042416	dopamine biosynthetic process
GO:0042417	dopamine metabolic process
GO:0042551	neuron maturation
GO:0043085	positive regulation of catalytic activity
GO:0043401	steroid hormone mediated signaling pathway
GO:0043524	negative regulation of neuron apoptotic process
GO:0043576	regulation of respiratory gaseous exchange
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051866	general adaptation syndrome
GO:0071542	dopaminergic neuron differentiation