Version 5.4
Bos taurus Gene: GIGYF2
Summary
InnateDB Gene IDBG-641793.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GIGYF2
Gene Name PERQ amino acid-rich with GYF domain-containing protein 2
Synonyms TNRC15
Species Bos taurus
Ensembl Gene ENSBTAG00000014079
Encoded Proteins
IDBP-694209
PERQ amino acid-rich with GYF domain-containing protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204120:
The protein encoded by this gene interacts with GRB10 and may be involved in the regulation of tyrosine kinase receptor signaling. This gene contains CAG repeats, and the encoded protein contains stretches glutamine and glutamic acid residues. Defects in this gene are a cause of Parkinson disease type 11 (PARK11). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
This gene contains CAG trinucleotide repeats and encodes a protein containing several stretches of polyglutamine residues. The encoded protein may be involved in the regulation of tyrosine kinase receptor signaling. This gene is located in a chromosomal region that was genetically linked to Parkinson disease type 11, and mutations in this gene were thought to be causative for this disease. However, more recent studies in different populations have been unable to replicate this association. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:113064293-113194137
Strand Forward strand
Band
Transcripts
ENSBTAT00000018720 ENSBTAP00000018720
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.
Predicted by orthology
Total 35 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0007631 feeding behavior
GO:0008344 adult locomotory behavior
GO:0009791 post-embryonic development
GO:0017148 negative regulation of translation
GO:0021522 spinal cord motor neuron differentiation
GO:0031571 mitotic G1 DNA damage checkpoint
GO:0035264 multicellular organism growth
GO:0044267 cellular protein metabolic process
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048873 homeostasis of number of cells within a tissue
GO:0050881 musculoskeletal movement
GO:0050885 neuromuscular process controlling balance
Cellular Component
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000204120
View Gene Order
ENSMUSG00000048000
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.70542 Bt.77827
RefSeq NM_001101877
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca