InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.53393

Summary

InnateDB Gene

IDBG-641842.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.53393

Gene Name

rho-related GTP-binding protein RhoH precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000013451

Encoded Proteins

IDBP-694242

rho-related GTP-binding protein RhoH precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168421:
The protein encoded by this gene is a member of the Ras superfamily of small GTPases. Expression of a chimeric transcript of LAZ3 and this gene has been reported as a result of the translocation t(3;4) in non-Hodgkin's lymphomas. This gene encodes a small G-like protein, and unlike most other small G proteins which are expressed ubiquitously, this gene is transcribed only in hemopoietic cells. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal translocations in non-Hodgkin\'s lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome 3, leading to the production of fusion transcripts. Alternative splicing in the 5\' untranslated region results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:60848686-60896785

Strand

Forward strand

Band

Transcripts

ENSBTAT00000017893

ENSBTAP00000017893

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019210	kinase inhibitor activity

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0030217	T cell differentiation
GO:0042326	negative regulation of phosphorylation
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045576	mast cell activation