InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rhoh

Summary

InnateDB Gene

IDBG-167092.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rhoh

Gene Name

ras homolog gene family, member H

Synonyms

5830400A04Rik; Arhh; AU019774

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029204

Encoded Proteins

IDBP-167094

ras homolog gene family, member H

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168421:
The protein encoded by this gene is a member of the Ras superfamily of small GTPases. Expression of a chimeric transcript of LAZ3 and this gene has been reported as a result of the translocation t(3;4) in non-Hodgkin's lymphomas. This gene encodes a small G-like protein, and unlike most other small G proteins which are expressed ubiquitously, this gene is transcribed only in hemopoietic cells. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal translocations in non-Hodgkin\'s lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome 3, leading to the production of fusion transcripts. Alternative splicing in the 5\' untranslated region results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:65863569-65896700

Strand

Forward strand

Band

C3.1

Transcripts

ENSMUST00000031106

ENSMUSP00000031106

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019210	kinase inhibitor activity

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0030217	T cell differentiation
GO:0042326	negative regulation of phosphorylation
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045576	mast cell activation

Cellular Component

GO:0001772	immunological synapse
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000168421

View Gene Order

ENSBTAG00000013451

Not yet available

Pathways

NETPATH

REACTOME

REACT_206918

Signaling by Rho GTPases pathway

REACT_210090

Rho GTPase cycle pathway

REACT_188257

Signal Transduction pathway

KEGG

mmu04670

Leukocyte transendothelial migration pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_11051

Rho GTPase cycle pathway

REACT_11044

Signaling by Rho GTPases pathway

REACT_111102

Signal Transduction pathway

KEGG

hsa04670

Leukocyte transendothelial migration pathway

INOH

PID NCI

Cross-References

SwissProt

Q9D3G9

TrEMBL

Q504M6

UniProt Splice Variant

Entrez Gene

74734

UniGene

Mm.20323 Mm.399618

RefSeq

NM_001081105

OMIM

CCDS

CCDS39100

HPRD

IMGT

MGI ID

MGI:1921984

MGI Symbol

Rhoh

EMBL

AK017885 AK137909 AK138090 BC094937 CH466524

GenPept

AAH94937 BAB30987 BAE23513 BAE23551 EDL37756

RNA Seq Atlas

74734