Version 5.4
Bos taurus Gene: ATG16L1
Summary
InnateDB Gene IDBG-641847.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATG16L1
Gene Name autophagy-related protein 16-1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003928
Encoded Proteins
IDBP-694277
ATG16 autophagy related 16-like 1 (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 19898471
[Homo sapiens] ATG16L1 is involved in autophagy where it is recruited to the plasma membrane at the site of bacterial entry by NOD1 and NOD2.
PMID 20200479
[Homo sapiens] ATG16L1, a critical autophagy protein, is recruited to the plasma membrane by NOD2 during bacterial invasion.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000085978:
The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:113578537-113621347
Strand Forward strand
Band
Transcripts
ENSBTAT00000005131 ENSBTAP00000005131
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.
Predicted by orthology
Total 35 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0039689 negative stranded viral RNA replication
Cellular Component
GO:0000421 autophagic vacuole membrane
GO:0005776 autophagic vacuole
GO:0005930 axoneme
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000085978
View Gene Order
ENSMUSG00000026289
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04140
Regulation of autophagy pathway
mmu04140
Regulation of autophagy pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq XM_005204950
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca