Version 5.4
Bos taurus Gene: ACSS2
Summary
InnateDB Gene IDBG-641970.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACSS2
Gene Name acetyl-coenzyme A synthetase, cytoplasmic
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013303
Encoded Proteins
IDBP-694386
acetyl-coenzyme A synthetase, cytoplasmic
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131069:
This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:64794728-64841518
Strand Forward strand
Band
Transcripts
ENSBTAT00000017694 ENSBTAP00000017694
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003987 acetate-CoA ligase activity
Biological Process
GO:0006085 acetyl-CoA biosynthetic process
GO:0008152 metabolic process
GO:0008610 lipid biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000131069
View Gene Order
ENSMUSG00000027605
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_34
Ethanol oxidation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
REACT_249802
Phase 1 - Functionalization of compounds pathway
REACT_260489
Ethanol oxidation pathway
REACT_188937
Metabolism pathway
REACT_232343
Biological oxidations pathway
KEGG
hsa00010
Glycolysis / Gluconeogenesis pathway
hsa00620
Pyruvate metabolism pathway
hsa00640
Propanoate metabolism pathway
mmu00010
Glycolysis / Gluconeogenesis pathway
mmu00640
Propanoate metabolism pathway
mmu00620
Pyruvate metabolism pathway
INOH
INOH website
Propanoate metabolism pathway
INOH website
Pyruvate metabolism pathway
PID NCI
hdac_classiii_pathway
Signaling events mediated by HDAC Class III
Cross-References
SwissProt
TrEMBL A7YWF1
UniProt Splice Variant
Entrez Gene 506459
UniGene Bt.29433
RefSeq NM_001105339
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC134532 DAAA02036514
GenPept AAI34533
RNA Seq Atlas 506459

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca