InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GSS

Summary

InnateDB Gene

IDBG-641979.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GSS

Gene Name

Glutathione synthetase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003504

Encoded Proteins

IDBP-694391

glutathione synthetase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100983:
Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:64842138-64867355

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000004559

ENSBTAP00000004559

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0004363	glutathione synthase activity
GO:0005524	ATP binding
GO:0016874	ligase activity
GO:0042803	protein homodimerization activity
GO:0043295	glutathione binding
GO:0046872	metal ion binding