InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gss

Summary

InnateDB Gene

IDBG-210630.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gss

Gene Name

glutathione synthetase

Synonyms

AI314904; GS-A/GS-B; GSH-S

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027610

Encoded Proteins

IDBP-210632

glutathione synthetase

IDBP-719491

IDBP-534759

glutathione synthetase

IDBP-541812

glutathione synthetase

IDBP-719498

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100983:
Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:155563181-155592810

Strand

Reverse strand

Band

Transcripts

ENSMUST00000079691	ENSMUSP00000078630
ENSMUST00000130881	ENSMUSP00000135319
ENSMUST00000140860
ENSMUST00000126322	ENSMUSP00000117266
ENSMUST00000157008
ENSMUST00000155347	ENSMUSP00000122662
ENSMUST00000137305
ENSMUST00000176415
ENSMUST00000175993	ENSMUSP00000135392

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004363	glutathione synthase activity
GO:0005524	ATP binding
GO:0016594	glycine binding
GO:0042277	peptide binding
GO:0042803	protein homodimerization activity
GO:0043295	glutathione binding

Biological Process

GO:0006750	glutathione biosynthetic process
GO:0007568	aging
GO:0009410	response to xenobiotic stimulus
GO:0031667	response to nutrient levels
GO:0034612	response to tumor necrosis factor
GO:0043200	response to amino acid
GO:0046686	response to cadmium ion