Version 5.4
Bos taurus Gene: GP6
Summary
InnateDB Gene IDBG-642023.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GP6
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000047175
Encoded Proteins
IDBP-694438
glycoprotein VI (platelet)
IDBP-694440
glycoprotein VI (platelet)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000088053:
This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:62935386-62945850
Strand Reverse strand
Band
Transcripts
ENSBTAT00000065426 ENSBTAP00000054078
ENSBTAT00000063245 ENSBTAP00000055707
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005518 collagen binding
Biological Process
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000088053
View Gene Order
ENSMUSG00000078810
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_1230
Platelet Adhesion to exposed collagen pathway
REACT_1695
GPVI-mediated activation cascade pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_604
Hemostasis pathway
REACT_224553
Hemostasis pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_225107
Platelet Adhesion to exposed collagen pathway
REACT_220092
GPVI-mediated activation cascade pathway
KEGG
hsa04512
ECM-receptor interaction pathway
mmu04512
ECM-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq XM_003585058
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca