InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.55896

Summary

InnateDB Gene

IDBG-642041.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.55896

Gene Name

lysosomal Pro-X carboxypeptidase precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000033731

Encoded Proteins

IDBP-694457

lysosomal Pro-X carboxypeptidase precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137509:
The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:12820130-12908442

Strand

Forward strand

Band

Transcripts

ENSBTAT00000047906

ENSBTAP00000045060

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008236	serine-type peptidase activity

Biological Process

GO:0002155	regulation of thyroid hormone mediated signaling pathway
GO:0002353	plasma kallikrein-kinin cascade
GO:0003085	negative regulation of systemic arterial blood pressure
GO:0006508	proteolysis
GO:0042593	glucose homeostasis
GO:0043535	regulation of blood vessel endothelial cell migration
GO:0060055	angiogenesis involved in wound healing
GO:0097009	energy homeostasis
GO:2000377	regulation of reactive oxygen species metabolic process