Version 5.4
Bos taurus Gene: GAS2
Summary
InnateDB Gene IDBG-642237.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GAS2
Gene Name growth arrest-specific protein 2
Synonyms GAS-2
Species Bos taurus
Ensembl Gene ENSBTAG00000021654
Encoded Proteins
IDBP-694678
growth arrest-specific protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148935:
The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 29:22275086-22423775
Strand Reverse strand
Band
Transcripts
ENSBTAT00000028855 ENSBTAP00000028855
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007050 cell cycle arrest
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000148935
View Gene Order
ENSMUSG00000030498
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13541
Caspase-mediated cleavage of cytoskeletal proteins pathway
REACT_107
Apoptotic cleavage of cellular proteins pathway
REACT_995
Apoptotic execution phase pathway
REACT_578
Apoptosis pathway
REACT_258521
Apoptosis pathway
REACT_224460
Apoptotic cleavage of cellular proteins pathway
REACT_210562
Caspase-mediated cleavage of cytoskeletal proteins pathway
REACT_207035
Apoptotic execution phase pathway
KEGG
INOH
PID NCI
caspase_pathway
Caspase Cascade in Apoptosis
Cross-References
SwissProt
TrEMBL A8E4Q5
UniProt Splice Variant
Entrez Gene 614840
UniGene Bt.26440
RefSeq NM_001105001
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC151514 DAAA02062879 DAAA02062880 DAAA02062881 DAAA02062882
GenPept AAI51515
RNA Seq Atlas 614840

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca