InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PYCR1

Summary

InnateDB Gene

IDBG-642322.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PYCR1

Gene Name

Pyrroline-5-carboxylate reductase 1, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000042

Encoded Proteins

IDBP-694775

Pyrroline-5-carboxylate reductase 1, mitochondrial

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183010:
This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternate splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:51567328-51571991

Strand

Forward strand

Band

Transcripts

ENSBTAT00000000046

ENSBTAP00000000046

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004735	pyrroline-5-carboxylate reductase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042802	identical protein binding
GO:0051287	NAD binding

Biological Process

GO:0006561	proline biosynthetic process
GO:0006950	response to stress
GO:0008652	cellular amino acid biosynthetic process
GO:0034599	cellular response to oxidative stress
GO:0046168	glycerol-3-phosphate catabolic process
GO:0051881	regulation of mitochondrial membrane potential
GO:0055114	oxidation-reduction process
GO:0055129	L-proline biosynthetic process