Bos taurus Gene: SLA2
Summary
InnateDB Gene IDBG-642473.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLA2
Gene Name src-like-adapter 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000040607
Encoded Proteins
src-like-adapter 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101082:
This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:66368694-66395549
Strand Reverse strand
Band
Transcripts
ENSBTAT00000026137 ENSBTAP00000026137
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0009967 positive regulation of signal transduction
GO:0042110 T cell activation
GO:0050849 negative regulation of calcium-mediated signaling
Cellular Component
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
TCR pathway
BCR pathway
REACTOME
KEGG
INOH
PID NCI
TCR signaling in naïve CD4+ T cells
Cross-References
SwissProt
TrEMBL A0JNA5
UniProt Splice Variant
Entrez Gene 514398
UniGene Bt.51764
RefSeq NM_001035294
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC126586 DAAA02036537
GenPept AAI26587
RNA Seq Atlas 514398