InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GLI2

Summary

InnateDB Gene

IDBG-642543.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLI2

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011682

Encoded Proteins

IDBP-695007

GLI family zinc finger 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000074047:
This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:72977209-73168370

Strand

Forward strand

Band

Transcripts

ENSBTAT00000015510

ENSBTAP00000015510

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001501	skeletal system development
GO:0001649	osteoblast differentiation
GO:0001701	in utero embryonic development
GO:0001822	kidney development
GO:0002009	morphogenesis of an epithelium
GO:0002062	chondrocyte differentiation
GO:0002076	osteoblast development
GO:0006355	regulation of transcription, DNA-templated
GO:0007224	smoothened signaling pathway
GO:0007389	pattern specification process
GO:0007411	axon guidance
GO:0007418	ventral midline development
GO:0007442	hindgut morphogenesis
GO:0007507	heart development
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008589	regulation of smoothened signaling pathway
GO:0009913	epidermal cell differentiation
GO:0009953	dorsal/ventral pattern formation
GO:0009954	proximal/distal pattern formation
GO:0021508	floor plate formation
GO:0021513	spinal cord dorsal/ventral patterning
GO:0021517	ventral spinal cord development
GO:0021522	spinal cord motor neuron differentiation
GO:0021696	cerebellar cortex morphogenesis
GO:0021775	smoothened signaling pathway involved in ventral spinal cord interneuron specification
GO:0021776	smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
GO:0021904	dorsal/ventral neural tube patterning
GO:0021915	neural tube development
GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021965	spinal cord ventral commissure morphogenesis
GO:0021983	pituitary gland development
GO:0030154	cell differentiation
GO:0030324	lung development
GO:0030879	mammary gland development
GO:0030902	hindbrain development
GO:0032331	negative regulation of chondrocyte differentiation
GO:0035295	tube development
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042733	embryonic digit morphogenesis
GO:0045666	positive regulation of neuron differentiation
GO:0045740	positive regulation of DNA replication
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048566	embryonic digestive tract development
GO:0048589	developmental growth
GO:0048646	anatomical structure formation involved in morphogenesis
GO:0048666	neuron development
GO:0048754	branching morphogenesis of an epithelial tube
GO:0048856	anatomical structure development
GO:0060032	notochord regression
GO:0060322	head development
GO:0060513	prostatic bud formation
GO:0060603	mammary gland duct morphogenesis
GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0071407	cellular response to organic cyclic compound
GO:0090103	cochlea morphogenesis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005929	cilium
GO:0016020	membrane
GO:0016607	nuclear speck
GO:0031512	motile primary cilium
GO:0072372	primary cilium
GO:0097542	ciliary tip