Version 5.4
Homo sapiens Gene: GLI2
Summary
InnateDB Gene IDBG-68270.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GLI2
Gene Name GLI family zinc finger 2
Synonyms HPE9; PHS2; THP1; THP2
Species Homo sapiens
Ensembl Gene ENSG00000074047
Encoded Proteins
IDBP-68272
GLI family zinc finger 2
IDBP-68274
GLI family zinc finger 2
IDBP-68276
GLI family zinc finger 2
IDBP-602406
GLI family zinc finger 2
IDBP-385265
GLI family zinc finger 2
IDBP-385267
GLI family zinc finger 2
IDBP-385268
GLI family zinc finger 2
IDBP-385269
GLI family zinc finger 2
IDBP-385270
GLI family zinc finger 2
IDBP-385273
GLI family zinc finger 2
IDBP-385276
GLI family zinc finger 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:120735623-120992653
Strand Forward strand
Band q14.2
Transcripts
ENST00000341310 ENSP00000344473
ENST00000314490 ENSP00000312694
ENST00000361492 ENSP00000354586
ENST00000360874 ENSP00000441454
ENST00000418323 ENSP00000398992
ENST00000445186 ENSP00000397488
ENST00000452692 ENSP00000403715
ENST00000438299 ENSP00000400593
ENST00000452319 ENSP00000390436
ENST00000437950 ENSP00000415773
ENST00000435313
ENST00000433812 ENSP00000402383
ENST00000482119
ENST00000472722
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 11 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0001649 osteoblast differentiation
GO:0001701 in utero embryonic development
GO:0001822 kidney development
GO:0002009 morphogenesis of an epithelium
GO:0002062 chondrocyte differentiation
GO:0002076 osteoblast development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007224 smoothened signaling pathway
GO:0007389 pattern specification process
GO:0007411 axon guidance
GO:0007418 ventral midline development
GO:0007442 hindgut morphogenesis
GO:0007507 heart development
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008589 regulation of smoothened signaling pathway
GO:0009612 response to mechanical stimulus
GO:0009913 epidermal cell differentiation
GO:0009953 dorsal/ventral pattern formation
GO:0009954 proximal/distal pattern formation
GO:0021508 floor plate formation
GO:0021513 spinal cord dorsal/ventral patterning
GO:0021517 ventral spinal cord development
GO:0021522 spinal cord motor neuron differentiation
GO:0021696 cerebellar cortex morphogenesis
GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification
GO:0021776 smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
GO:0021904 dorsal/ventral neural tube patterning
GO:0021915 neural tube development
GO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021965 spinal cord ventral commissure morphogenesis
GO:0021983 pituitary gland development
GO:0030154 cell differentiation
GO:0030324 lung development
GO:0030879 mammary gland development
GO:0030902 hindbrain development
GO:0032331 negative regulation of chondrocyte differentiation
GO:0033089 positive regulation of T cell differentiation in thymus
GO:0035295 tube development
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042733 embryonic digit morphogenesis
GO:0045666 positive regulation of neuron differentiation
GO:0045740 positive regulation of DNA replication
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048566 embryonic digestive tract development
GO:0048589 developmental growth
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048666 neuron development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048856 anatomical structure development
GO:0060032 notochord regression
GO:0060322 head development
GO:0060513 prostatic bud formation
GO:0060603 mammary gland duct morphogenesis
GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0071407 cellular response to organic cyclic compound
GO:0090103 cochlea morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005929 cilium
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0031512 motile primary cilium
GO:0072372 primary cilium
GO:0097542 ciliary tip
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000048402
View Gene Order
ENSBTAG00000011682
Not yet available
Pathways
NETPATH
NetPath_10
Hedgehog pathway
REACTOME
REACT_228134
Signaling by Hedgehog pathway
REACT_206597
Degradation of GLI2 by the proteasome pathway
REACT_111102
Signal Transduction pathway
REACT_267634
Hedgehog 'off' state pathway
KEGG
hsa04340
Hedgehog signaling pathway pathway
hsa05217
Basal cell carcinoma pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
Hedgehog signaling pathway pathway
PID NCI
hedgehog_2pathway
Signaling events mediated by the Hedgehog family
hedgehog_glipathway
Hedgehog signaling events mediated by Gli proteins
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.111867
RefSeq NM_005270
HUGO
OMIM
CCDS CCDS33283
HPRD 01312
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca