InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: APLP2

Summary

InnateDB Gene

IDBG-642875.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APLP2

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016168

Encoded Proteins

IDBP-695485

amyloid beta (A4) precursor-like protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000084234:
This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer\'s disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:36878509-36906465

Strand

Forward strand

Band

Transcripts

ENSBTAT00000021524

ENSBTAP00000021524

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0042802	identical protein binding
GO:0046914	transition metal ion binding

Biological Process

GO:0001967	suckling behavior
GO:0006878	cellular copper ion homeostasis
GO:0007176	regulation of epidermal growth factor-activated receptor activity
GO:0007617	mating behavior
GO:0007626	locomotory behavior
GO:0008203	cholesterol metabolic process
GO:0010951	negative regulation of endopeptidase activity
GO:0030198	extracellular matrix organization
GO:0030900	forebrain development
GO:0030901	midbrain development
GO:0043393	regulation of protein binding
GO:0050885	neuromuscular process controlling balance

Cellular Component

GO:0005634	nucleus
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000084234

View Gene Order

ENSMUSG00000031996

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

F1N226

UniProt Splice Variant

Entrez Gene

785005

UniGene

Bt.49768

RefSeq

XM_001251234 XM_002699235

HUGO

HGNC:598

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02063376

GenPept

RNA Seq Atlas

785005