Version 5.4
Bos taurus Gene: RAD23A
Summary
InnateDB Gene IDBG-642886.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAD23A
Gene Name UV excision repair protein RAD23 homolog A
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000015116
Encoded Proteins
IDBP-695387
UV excision repair protein RAD23 homolog A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 23357418
[Homo sapiens] RAD23A is a negative regulator of the RIG-I anti-viral signalling pathway by mediating the ubiquitin-dependent proteasomal degradation of TRAF2.
PMID 23357418
[Mus musculus] RAD23A is a negative regulator of the RIG-I anti-viral signalling pathway by mediating the ubiquitin-dependent proteasomal degradation of TRAF2.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179262:
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:13724192-13730226
Strand Reverse strand
Band
Transcripts
ENSBTAT00000020113 ENSBTAP00000020113
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 110 interaction(s) predicted by orthology.
Predicted by orthology
Total 110 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003684 damaged DNA binding
GO:0005515 protein binding
GO:0031593 polyubiquitin binding
GO:1990381 ubiquitin-specific protease binding
Biological Process
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006974 cellular response to DNA damage stimulus
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045070 positive regulation of viral genome replication
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000179262
View Gene Order
ENSMUSG00000003813
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03420
Nucleotide excision repair pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
mmu03420
Nucleotide excision repair pathway
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt A3KMV2
TrEMBL
UniProt Splice Variant
Entrez Gene 540564
UniGene Bt.23124
RefSeq NM_001082614 XM_005208675
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC133282
GenPept AAI33283
RNA Seq Atlas 540564

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca